cover image
Bicycle Therapeutics

Bicycle Therapeutics

www.bicycletherapeutics.com

2 Jobs

340 Employees

About the Company

Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company that is harnessing the power of bicyclic peptides and leveraging Nobel Prize-winning science to develop a new and differentiated class of medicines to treat cancer and other diseases. Bicycle(r) molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development.

The company is evaluating zelenectide pevedotin, previously BT8009, a Bicycle(r) Toxin Conjugate (BTC(r)) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist(r) (Bicycle TICA(r)) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle(r) Radio Conjugates (BRC(tm)) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle(r) technology to develop therapies for diseases beyond oncology.

Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.

Listed Jobs

Company background Company brand
Company Name
Bicycle Therapeutics
Job Title
Director, Research Project Manager
Job Description
Cambridge, United kingdom
On site
16-10-2025
Company background Company brand
Company Name
Bicycle Therapeutics
Job Title
Associate Director, Technical Architect
Job Description
**Job title:** Associate Director, Technical Architect **Role Summary:** Lead the design, implementation, and governance of a scalable, cloud‑native data ecosystem that supports research, data science, and business decision‑making. Serve as a technical strategist, hands‑on architect, and cross‑functional partner driving data integration, quality, and automation. **Expectations:** - Deliver end‑to‑end data architecture solutions on large, heterogeneous datasets. - Champion best practices in data engineering, pipeline automation, and data governance. - Partner with research, analytics, and business units to translate data needs into robust technical solutions. - Maintain oversight of data quality, reliability, and compliance across all pipelines. **Key Responsibilities:** 1. **Strategic Planning & Leadership** - Define company‑wide data architecture strategy and roadmap. - Evaluate emerging technologies; recommend solutions for ingestion, storage, and access. - Lead and mentor a team of data engineers, designers, and analysts. 2. **Operational Delivery** - Design and implement scalable ETL/ELT pipelines for internal and external data sources (APIs, databases, file systems). - Build data lakes, warehouses, and analytic catalogs on cloud platforms. - Automate data ingestion, transformation, and load processes; ensure fault tolerance and performance. 3. **Data Products & Insight Enablement** - Develop data products, dashboards, and reports that expose actionable insights to data scientists and business stakeholders. - Establish data modeling standards and documentation for reuse across projects. 4. **Governance & Quality Assurance** - Implement strong data quality, validation, and monitoring frameworks. - Enforce data governance policies, metadata management, and security controls. 5. **Stakeholder Collaboration** - Act as a liaison between technology, research, and business units to prioritize data initiatives. - Facilitate integration of new data sources and ensure alignment with organizational goals. **Required Skills:** - Extensive expertise in data engineering, cloud architecture (AWS, GCP, or Azure), and data pipeline automation. - Proficiency with ETL/ELT frameworks (e.g., dbt, Airflow, Prefect, Snowflake, BigQuery, Redshift, Athena). - Strong programming skills in Python, SQL, and optionally Scala/Java. - Experience with data modeling, metadata management, and governance tools. - Knowledge of data security, compliance (GDPR, HIPAA), and documentation standards. - Leadership and project management abilities; capability to manage cross‑functional teams and multi‑phase projects. **Required Education & Certifications:** - Bachelor’s or Master’s degree in Computer Science, Informatics, Engineering, or a related technical field. - Relevant certifications preferred: Certified Data Management Professional (CDMP), SnowPro/Redshift/BigQuery certifications, AWS/Azure/GCP data engineering credentials.
Cambridge, United kingdom
On site
08-12-2025