4D Molecular Therapeutics

www.4dmoleculartherapeutics.com

1 Job

213 Employees

About the Company

4DMT is a clinical stage biopharma company inventing and developing innovative products to unlock the full potential of genetic medicine to treat large market and rare diseases. Our vector discovery platform Therapeutic Vector Evolution harnesses the power of directed evolution, a Nobel Prize-winning technology, with approximately one billion synthetic AAV capsid-derived sequences to invent customized and evolved vectors with improved therapeutic profiles compared to wild-type vectors. Our product design, development and manufacturing engine empowers us to efficiently create our valuable and diverse product pipeline. This combination of bold innovation and relentless execution gives 4DMT the capability to revolutionize genetic medicines and to strive for potential curative therapies. We have built a deep portfolio of genetic medicine product candidates, with five product candidates in clinical trials for seven patient populations. We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our 4 Guiding Principles drive the way we work together: - Dare to Cure - Break Boundaries - Beyond Yourself - Prepare & Execute Relentlessly Join us in creating the future of genetic medicine.

Listed Jobs

Company Name: 4D Molecular Therapeutics
Job Title: Executive Director, Biostatistics
Job Description: **Job Title:** Executive Director, Biostatistics **Role Summary:** Lead statistical strategy and oversight across global development programs within a late‑stage biotech environment. Manage internal and CRO statisticians, develop and enforce policies and SOPs, provide regulatory and publication statistical input, and mentor the biostatistics team. **Expectations:** - 12+ years pharmaceutical industry experience with a PhD (or 14+ years with an MS). - 8+ years of statistical leadership/management. - Proven record of delivering high‑quality analyses for Phase 3 and beyond. - Strong partnership with clinical, regulatory, and business functions. - Minimal travel (<5%). **Key Responsibilities:** - Design, analyze, interpret, and report on clinical data for global development programs. - Oversee CRO statistical work, ensuring adherence to quality standards and timelines. - Draft and review statistical sections of regulatory submissions and scientific manuscripts. - Lead preparation of statistical inputs for podium presentations and payer discussions. - Develop, update, and enforce SOPs and policies to improve processes and compliance. - Mentor statisticians, driving professional growth and team cohesion. - Stay current on scientific advances, CDISC standards, and regulatory updates for novel endpoints and rare diseases. **Required Skills:** - Expert knowledge of clinical trial design, statistical methodology, and data synthesis. - Advanced proficiency in SAS programming, EAST, and nQuery; experience with CDISC SDTM and ADaM datasets. - Strong analytical, problem‑solving, and decision‑making abilities. - Excellent communication skills for cross‑functional collaboration and regulatory interactions. - Leadership and project management experience in a fast‑paced biotech or pharma setting. **Required Education & Certifications:** - PhD in Statistics, Biostatistics, or a related field (or Master’s with extensive pharma experience). - Minimum 12 years of industry experience for PhD holders; 14 years for MS holders. ---