Crownlands

www.crownlands.com

1 Job

6 Employees

About the Company

Crownlands develops precision medicines for neurodegenerative and CNS diseases with data and scale. Our goal is to give everyone and their brains twenty more sharp, healthy, happy years to do what they love.

Listed Jobs

Company Name: Crownlands
Job Title: Computational Biology Intern
Job Description: Job Title: Computational Biology Intern Role Summary: Assume full ownership of single‑cell analysis projects on real human neurology data. Design and implement scalable, reproducible pipelines; validate and harden gene‑program and network workflows; translate complex modeling outputs into clear biological insights and actionable artifacts for downstream teams. Expectations: * Deliver robust, decision‑driving analyses in a 12‑16 week internship. * Work independently with minimal supervision, turning ambiguous problems into finished, reproducible work. * Demonstrate clear communication of methods and results to cross‑functional stakeholders. * Produce code and documentation that follows best practices (version control, testing, CI/CD). Key Responsibilities: * Cell‑type identification and lineage refinement to enhance depth and accuracy for targeted lineages. * Develop and evaluate robust gene‑program and network inference pipelines, ensuring stability across donors and batches (e.g., downsampling, perturbation tests). * Apply latent‑factor and state‑modeling techniques (pathway/state scoring, decomposition) and transform outputs into interpretable biology and usable artifacts. * Enhance internal analysis and machine‑learning tooling: build reusable pipelines, libraries, and CI/CD frameworks to accelerate iteration pace. * Create MCP‑compatible standardized analysis tools enabling internal agents to query curated outputs and retrieve structured synthesis (tables, plots, metrics). Required Skills: * Hands‑on single‑cell analysis using Seurat and/or Scanpy. * Proficient programming in R and/or Python; solid UNIX command‑line proficiency (environments, CLI workflows, basic debugging). * Proven track record of delivering reproducible work (public GitHub repo, publication, preprint, poster, or detailed project write‑up). * Ability to navigate ambiguous problem spaces and drive work to completion. Preferred Skills: * Familiarity with neuroscience or neurodegenerative disease research. * Experience building reusable tooling (packages, pipelines, CI/testing, containers, workflow orchestration, or cloud/HPC). * Background in robustness/stability evaluations across donors/batches (downsampling, perturbation testing, sensitivity analyses). Required Education & Certifications: * Senior student (undergraduate, master’s, or PhD) in Computer Science, Biology, Computational Biology, Genetics, Neuroscience, or a closely related field. * No specific certifications required.

San francisco, United states

On site

Fresher

27-01-2026