Job Specifications
Date Posted: 08/07/2025
Req ID:44678
Faculty/Division: Faculty of Arts & Science
Department: Acceleration Consortium
Campus: St. George (Downtown Toronto)
Description
The Acceleration Consortium (AC) at the University of Toronto (U of T) is leading a transformative shift in scientific discovery that will accelerate technology development and commercialization. The AC is a global community of academia, industry, and government that leverages the power of artificial intelligence (AI), robotics, materials sciences, and high-throughput chemistry to create self-driving laboratories (SDLs), also called materials acceleration platforms (MAPs). These autonomous labs rapidly design materials and molecules needed for a sustainable, healthy, and resilient future, with applications ranging from renewable energy and consumer electronics to drugs. AC Staff Scientists will advance the field of AI-driven autonomous discovery and develop the materials and molecules required to address society's largest challenges, such as climate change, water pollution, and future pandemics.
The Acceleration Consortium (AC) promotes an inclusive research environment and supports the EDI priorities of the unit.
The Acceleration Consortium received a $200M Canadian First Research Excellence Grant for seven years to develop self-driving labs for chemistry and materials, the largest ever grant to a Canadian University. This grant will provide the Acceleration Consortium with seven years of funding to execute its vision.
The AC is developing seven advanced SDLs plus an AI and Automation lab:
SDL1 - Inorganic solid-state compounds for advanced materials and energy
SDL2 - Organic small molecules for sustainability and health
SDL3 - Medicinal chemistry for improving small molecule drug candidates
SDL4 - Polymers for materials science and biological applications
SDL5 - Formulations for pharmaceuticals, consumer products, and coatings
SDL6 - Biocompatibility with organoids / organ-on-a-chip
SDL7 - Synthetic scale-up of materials and molecules (University of British Columbia partner lab)
A central AI and Automation lab to support all the SDLs
Position Overview
We are seeking a motivated and skilled researcher to join the Acceleration Consortium working with the Human Organ Mimicry SDL. The Self-Driving Lab (SDL) focused on Human Organ Mimicry (HOM) embodies an autonomous artificial intelligence (AI)-assisted platform for culturing and screening high-fidelity models of functional tissues and diseases. In addition to fundamental capabilities like cell passaging and sample preparation, the platform will facilitate closed-loop optimization campaigns designed to optimize cell culture conditions (e.g., growth media and extracellular matrix support), automated generation of model-specific datasets and production of highly reproducible batches of cells with specific phenotypes (e.g., patient-derived organoids (PDOs) and differentiated iPSCs), and development of advanced automated workflows and AI tools (e.g., static and dynamic co-culture organ-on-a-chip (OOC) models, colony picking and bioprinting).
The ideal candidate should have strong expertise performing machine learning (ML), computational biology with the capability and/or experience to apply those skills toward imaging data (e.g., live cell microscopy). The successful candidate will contribute to advancing machine learning-driven analysis of high-content imaging data to achieve 1) better OOC tissue model functional evaluation and clinical benchmarking, 2) optimization on cost-efficient workflow and reproducibility. The candidate must have knowledge of current machine learning models, including their strengths, deficiencies, and strategies for (hyper)parameter optimization. Prior use of Bayesian optimization or other relevant active learning algorithms is preferred. Strong coding skills in Python or a comparable programming language are expected, with the ability to develop analysis pipelines and tools that meet project deadlines and are suitable for publication-quality research. The role will involve developing novel computational approaches for biological discovery and working collaboratively in an interdisciplinary research environment. Additional expertise related to biological knowledge of the wet lab experimentation required to gather imaging data is an optional benefit.
This posted position is for a Staff Scientist at SDL6 (Human Organ Mimicry).
Expertise That Is Desired
Computational expertise
Life science and physical science applications of machine learning in biology, bioengineering or molecular biology or any other relevant fields.
Programming and high-performance computing
Experience in design of computational pipelines for large-scale imaging
Experience with programming languages and scripting methods (i.e. Python, MATLAB, C++, CUDA, Bash, and/or SQL) and machine learning / deep learning methods
Active learning, exploration, optimal experiment design, Bayesian optimizati
About the Company
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