Job Specifications
About Us
The Curie Institute Research Center
The "Institut Curie" is a major player in the research and fight against cancer. It consists of a hospital and a Research Center
Institut Curie is a major player in cancer research and the fight against cancer. It consists of a hospital and a research center with more than 1000 employees with a strong international representation.
The objective of the Institut Curie Research Center is to develop fundamental research and use the knowledge generated to improve the diagnosis, prognosis and therapeutics of cancers within the continuum between fundamental research and innovation for the benefit of patients.
Mission
Job Description
Laboratory
The "Repair, Radiation and Innovative Anti-Cancer Therapies" team (U1021/UMR3347/Universite Paris-Saclay) investigates the changes at the cellular and molecular level induced by radiotherapy in the lung (Curras-Alonso et al. Nature Communications 2023). Using cutting-edge single cell technologies (scRNAseq, spatial transcriptomic), current projects aim at identifying key mechanisms underlying effects of radiotherapy on healthy tissue and tumor. To achieve these goals, the team is looking for a computational biologist to lead the bioinformatic analysis and integration of the different sets of data (scRNAseq, spatial transcriptomic, lipidomic). This position will benefit from the expertise of the lab as well as close interactions with radiation biologists of the team and external collaborations.
Missions
Data processing and Pipeline development: Design, implement, and maintain robust pipelines for processing scRNA-seq and spatial analysis including data quality control, normalization and batch effect correction.
Single cell and Spatial transcriptomic analysis: Perform clustering, cell-type annotation, trajectory inference, cell-cell communication.
Data integration: Apply statistical and machine learning approaches to integrate single cell and spatial analysis in order to identify molecular signatures and pathways underlying radiation-induced effects.
Collaboration: Work in close interaction with radiation biologists and collaborate with international partners through interdisciplinary projects.
Scientific communication: Present results in lab meetings, seminars, and international conferences as well as contribute to manuscripts, grant applications.
Profile
Desired profile
Education And Skills
PhD (or MSc with significant experience) in Bioinformatics, Computational Biology, Biostatistics, Systems Biology, or related field.
Solid background in molecular biology and/or single cell approaches is a strong plus.
Experience in interdisciplinary environments (biology + computation) highly valued.
Proficiency in R (Bioconductor, tidyverse), Python (NumPy, Pandas, scikit-learn) and Bash
Previous experiences in single cell RNA-seq (Seurat, Scanpy) and/or spatial analysis (Giotto, Squidpy) would be a plus.
Required Qualities
Rigor, autonomy, and problem-solving mindset.
Strong organizational skills and ability to work independently.
Team spirit, openness to international collaboration
Good written and oral communication skills (French and/or English desired).
All Our Opportunities Are Open To People With Disabilities.
Contract information
Type of contract: CDD
Starting date: 01/12/2025
Duration: 18 months that can be extended
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Orsay
Contact
Please send your CV, letter of motivation and 2 references, to
Publication date : 09/09/2025
Deadline for application: 15/11/2025
Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
Reference de l'offre : 7ov7hnqim6
About the Company
L’Institut Curie, premier centre français de recherche et de lutte contre le cancer, associe un centre de recherche de renommée internationale et un ensemble hospitalier de pointe qui prend en charge tous les cancers y compris les plus rares. Fondé en 1909 par Marie Curie, l’Institut Curie rassemble sur 3 sites (Paris, Saint-Cloud et Orsay) 3 800 chercheurs, médecins et soignants autour de ses 3 missions : recherche, soins et transmission des savoirs. Fondation reconnue d’utilité publique habilitée à recevoir des dons et des...
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